Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells
Summary: Colon cancer is a heterogeneous tumor driven by a subpopulation of Moss Wall Art cancer stem cells (CSCs).To study CSCs in colon cancer, we used limiting dilution spheroid and serial xenotransplantation assays to functionally define the frequency of CSCs in a panel of patient-derived cancer organoids.These studies demonstrated cancer organ